Germany discovers new method for measles virus to kill tumor stem cells for the first time

The Paul Ehrlich Institute in Germany discovered for the first time that cancer stem cells can be eliminated with viruses. Researchers at the institute performed genetic reprogramming of the measles virus and used this new virus to effectively control tumors in a variety of experimental animals. The related research results were published in the 2012 "Medical Cancer" professional journal.

Cancer tumors are made up of a variety of different abnormal cells, which can be treated by different methods such as radiotherapy and chemotherapy. But the cancer stem cells are recognized as the most difficult to treat by radiotherapy and chemotherapy, and it is also the source of cancer cell metastasis. To this end, researchers have been looking for treatments that can effectively control and eliminate cancer stem cells.

Researchers at the Paul-Ellich Institute have found that with the help of specific measles viruses, the growth of various tumors can be effectively controlled or even completely cured. To this end, they genetically reprogrammed measles viruses for common vaccines so that these viruses only infected specific cells that carry the CD133 protein on the cell surface (this protein is characteristic of cancer stem cells). They also conducted a cooperative experiment with the German Cancer Research Center (DKFZ) to verify the effectiveness of the treatment in experimental mice. Experiments show that gene reprogramming measles virus can obviously control the growth of liver cancer and colon cancer, and can even completely cure liver cancer.

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