In order to compare the correlation between Farr and ELISA to detect anti-double-stranded DNA antibodies and its correlation with disease activity, foreign researchers conducted a study in patients with systemic lupus erythematosus. A total of 550 SLE patients from 2940 clinical treatment centers were enrolled. The anti-double-stranded DNA antibody titers were detected by Farr and ELISA methods from January 1, 2000 to December 31, 2002. Correlation and the relationship between these two indicators and disease activity (SLE disease activity index 2000, kidney, central nervous system and vasculitis). It was found that the correlation between anti-double-stranded DNA antibodies detected by Farr and ELISA at the initial diagnosis was 0.46. If the result of Farr test is normal, the result of ELISA test may be normal or abnormal. The relationship between abnormal Farr test results and high SLEDAI-2K scores is more obvious than normal Farr test results (6.2 vs 4.3, P <0.0001), but the relationship between normal ELISA test results and SLEDAI-2K scores is not obvious (5.9 vs 4.8, P = 0.04). Only the level of anti-double-stranded DNA antibody detected by Farr has a significant correlation with SLE nephropathy and vasculitis. The results of the two detection methods have no correlation with the central nervous system disease. The researchers pointed out that there is no correlation between Farr and ELISA in the detection of anti-double-stranded DNA antibodies in SLE patients. Because Farr is more closely related to disease activity, kidney disease and vasculitis, it is more advantageous than ELISA and has clinical value. Peripheral Devices and Consumables
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