Researchers from the Max Planck Institute for Biochemistry in Germany and the University of Copenhagen in Denmark found that acetate in the chemical composition of human proteins has a great influence on changes in human cells, whether it is cell division, DNA inheritance, or the process of cell aging. Acetate all functions as a molecular switch. This discovery will have important implications for the development of drugs to treat cancer, Alzheimer's disease and Parkinson's disease. The researchers found that the combination of protein molecules and acetate can control the on or off of specific functions of proteins, and through the acetylation of specific chemical enzymes, acetate can be separated from protein molecules. This reversible process has caused many changes in cells. Plays a decisive role. Researchers at the Max Planck Institute of Biochemistry in Germany used their own new technology to detect the combination of protein and acetate for the first time, and the process status of the entire protein molecular switch. More than 3600 molecules were found in about 1800 proteins. Switching nodes and discovering the ability of protein acetylation far exceeds what has been imagined so far. Researchers used to believe that protein acetylation only played a certain role in the gene regulation of the nucleus, and the latest research results show that all cell changes are related to this, such as cell division, inheritance of DNA information or DNA repair . Without acetylation, the cell loses its function. It is various enzymes that acetylate proteins, such as Cdc28. This enzyme is necessary for the division of yeast cells. Without the participation of this enzyme, the acetyl switch will not work and the yeast cells will die. The defect of protein regulatory function is the root cause of many diseases. Therefore, it is of great significance to develop new drugs using the principle of protein acetylation, especially for the treatment of cancer. Researchers at the University of Copenhagen in Denmark believe that another important application area is the treatment of senile diseases such as Alzheimer's disease and Parkinson's disease. Although protein acetylation is important in biology and clinical medicine, researchers still have little understanding of the acetylation process of living cells. With the help of this latest research, researchers can have a more comprehensive view of the efficacy of acetyl switches Recognize and will greatly promote the development of related new drugs.
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