CYP2D6 Antibody Brochure Anti-CYP2D6 Antibody Information

Cat. Number: Rs-1027R

Quantity size: 0.1ml (dilute with pH 7.4 0.01 M PBS or diluent of antibody)

CYP2D6 Antibody Brochure Anti-CYP2D6 Antibody Information

Background: commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine ​​and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzymes substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1).
CYP2D6 Antibody Brochure Anti-CYP2D6 Antibody Information

Also known as: Cytochrome P450 2D6; CPD6; CYP2D; CYP2D6; CYP2DL1; CYPIID6; Cytochrome P450 family 2 subfamily D polypeptide 6; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; MGC120389; MGC120390; Microsomal monooxygenase; P450C2D; P450DB1; Xenobiotic monooxygenase.

CYP2D6 Antibody Brochure Anti-CYP2D6 Antibody Information

Specificity: · anti- CYP2D6 is a rabbit monoclonal antibody unconjugated

· Specific for CYP2D6 of human, rat, mouse and chicken

· Epitope mapping near the C terminus of CYP2D6 of human, rat mouse

and chicken

· Human, rat, mouse and chicken cross reacted

· Use for western blotting, elisa, immunoprecipitation

and immunohistochemistry

· Protein A affinity chromatography purification, purity:> 95%

· Isotype: IgG · mol wt: 48kDa

Application: · Western blotting: 1: 100-500

· Immunohistochemistry: 1: 100-500

· ELISA: 1: 500-1000

· Optimal working dilutions must be determined by the end user.

CYP2D6 Antibody Brochure Anti-CYP2D6 Antibody Information

Storage: Store at –20 ºC for one year. Avoid repeated freeze / thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºC. When reconstituted in sterile pH 7.4 0.01 M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ºC.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.