Conventional particle size measurement plays an important role in the pharmaceutical industry and other industries and is key to ensuring product quality. Dispersion is critical for any particle size measurement process, and there are two main approaches in laser diffraction systems: wet and dry. If the powder in the dry state is treated and the final product is a dry powder, the dry dispersion method is generally preferred. In the pharmaceutical industry, the active ingredients and excipients are usually treated in a dry form and the final state may be a dry powder, such as a dry powder inhaler. In the early stages of product development, pharmaceutical manufacturers may wish to use less than 100 mg of existing materials. The particle size of the dry powder sample was measured. In this application note, we measured only 5 mg of fine medicinal lactose aliquots and achieved good measurement reproducibility – meeting the reproducibility requirements of the ISO laser diffraction standard guidelines. We chose fine lactose as the active ingredient of the drug and a high-adhesive powder modeling material that is difficult to disperse.
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