German researchers have revealed a new mechanism by which cells protect themselves from stress. Dr. Kathrin Thedieck and Birgit Holzwarth from the University of Freiburg in Germany found that an element Astrin rarely studied in many cells played an important role in this process. Although Astrin has been known to play a role in cell division in the past, this is the first time scientists have confirmed its slow pressure function. Because tumor cells rely on high levels of Astrin to avoid cell death, Astrin may become an important drug target. The results of these studies were published in the well-known scientific journal "Cell" on August 15. Free radicals, like burning exhaust gas, are generated by external energy sources or cell metabolism, which can cause stress on the body's cells. It is believed that cell pressure promotes the occurrence of age-related diseases such as cancer, neurodegenerative diseases, and metabolic diseases. Dr. Thedieck said: "The protein complex mTORC1 plays an important role in balancing growth and degradation. Nutrients can activate mTORC1 to make cells grow. In addition, mTORC1 can help cells cope with moderate stress. However, when mTORC1 activity becomes excessive When it is high, the cell will initiate programmed cell death. When the pressure increases, we observed that stress granules prevent mTORC1 hyperactivation, thereby mediating cell death under transient pressure. However, until now, for control The molecular mechanism of this process is still unclear. " Thedieck and her research team now confirm that Astrin is a molecular chain between mTORC1 and stress particles. When faced with stress, Astrin recruits mTORC1 elements to stress particles, thereby limiting mTORC1 activity. "When we manipulate the cells to prevent Astrin production, mTORC1 becomes more active and the cells die earlier under stress," Thedieck said. In order to protect the potential application of their research in cancer treatment, researchers have applied for a patent. "In many tumors, the level of Astrin is increased, which suppresses the cell death that chemotherapy should have caused. Therefore, tumor cells survive. If we can take away their Astrin protective effect, we may be able to easily fight tumors in the future , "Thedieck said.
Leather Duffle Bags, a combination of utilitarian design and painstaking craftsmanship.
From the conscientious businessman to the discerning traveler, it is loved by one and all.
You can put everything you need in the duffle bag for traveling or go to gym .All said and done, if you have never owned a leather duffle bag before, then here is our complete guide to help you narrow down your choice, learn how to pick the right one and maintain it to ensure that you maximize your investment.
Duffel Bags,Duffel Gym Bag,Duffel Travel Bag,Dry Duffel Bag KAIPING XIN SUI YING LEATHER WARE CO.,LTD , https://www.paliobag.com